The Egami score calculator predicts the likelihood of a patient being unresponsive to intravenous immunoglobulin (IVIG) therapy by evaluating five clinical factors. Each factor is input as a boolean, representing whether the condition is present. The total score, ranging from 0 to 6, offers an interpretation of the IVIG resistance likelihood.

Here's how the calculator works:

Inputs are provided on five clinical conditions:
- Age of 6 months or less
- 4 or fewer days of illness at the time of initial treatment
- Alanine aminotransferase (ALT) level of at least 80 IU/L
- C-reactive protein level of at least 8 mg/dL
- Platelet count of 300,000/mcL or lower

Each condition has a specific score weight, reflecting its significance in the Egami score:

| Condition                                                   | Score Weight |
|-------------------------------------------------------------|--------------|
| Age of 6 months or less                                     | 1            |
| 4 or fewer days of illness at initial treatment             | 1            |
| ALT level of at least 80 IU/L                               | 2            |
| C-reactive protein level of at least 8 mg/dL                | 1            |
| Platelet count of 300,000/mcL or lower                      | 1            |

To compute the score, the sum of the weights for all present conditions is calculated. This total score forms the Egami score, indicating the likelihood of IVIG resistance.

Interpretation of the score is straightforward:
- A score of 0 to 2 suggests a lower likelihood of IVIG resistance.
- A score of 3 or more implies that IVIG-resistant disease is likely, with the model having a sensitivity of 76% and a specificity of 80%. Essentially, this indicates a 76% probability that patients with a score of 3 or more are resistant to IVIG therapy, while an 80% probability exists that those scoring below 3 are not resistant.

The Egami Score is a clinical calculator used to predict the unresponsiveness to Intravenous Immunoglobulin (IVIG) therapy in patients with Kawasaki disease. Kawasaki disease is a rare childhood illness that affects the blood vessels and can lead to serious complications, such as heart disease. The Egami Score is particularly useful in identifying patients who are at high risk of being unresponsive to IVIG therapy, which is the standard treatment for Kawasaki disease. This allows clinicians to consider alternative or additional treatments early in the disease course. The score is calculated based on several factors including age, days of illness, platelet count, and levels of aspartate aminotransferase (AST) and sodium. The Egami Score is not applicable to patients without Kawasaki disease or those who have already started IVIG therapy.

Egami score for predicting unresponsiveness to IVIG therapy