The Mayo Clinic Risk Stratification Model for Progression of Monoclonal Gammopathy of Undetermined Significance (MGUS) is a clinical calculator used in the field of hematology. This model is specifically designed for patients diagnosed with MGUS, a condition characterized by the presence of an abnormal protein in the blood, which can potentially progress to more serious conditions like multiple myeloma or other plasma cell disorders.
The clinical utility of this calculator is to stratify patients into risk groups (low, intermediate, and high) based on three factors: the amount of M protein, the type of M protein, and the ratio of free light chains in the blood. This risk stratification helps clinicians predict the likelihood of progression from MGUS to a malignant condition over a 20-year period, thereby guiding follow-up and management strategies.
There are no specific exclusion criteria for the use of this calculator. However, it should be noted that it is not applicable to patients who have already progressed to a malignant condition from MGUS. It is also less accurate in predicting progression in patients with non-IgM type MGUS, as the model was primarily developed based on patients with IgM type MGUS.
Reference
S Vincent Rajkumar, Robert A Kyle, Terry M Therneau et al. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood. 2005 Aug 1;106(3):812-7.
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