The Sano score calculator is designed to predict the likelihood of unresponsiveness to IVIG (Intravenous Immunoglobulin) therapy based on three specific clinical criteria: AST levels, total bilirubin levels, and C-reactive protein levels. Each input corresponds to a binary factor indicating whether certain thresholds have been met:

1. AST (Aspartate Aminotransferase) level ≥ 200 IU/L
2. Total Bilirubin level ≥ 0.9 mg/dL
3. C-reactive Protein level ≥ 7 mg/dL

Each of these conditions contributes a score of 1 if true. The total score is calculated by summing the individual scores for these conditions. 

The computation uses this scoring method:
- A value of true for any of the three criteria indicates that the level is above the specified threshold, contributing 1 point to the score.
- The combined score ranges from 0 to 3, where each criterion met increases the score by 1.

The total score is used to provide an interpretation regarding the likelihood of resistance to IVIG therapy:
- A score of 2 or 3 suggests that the patient is likely to have IVIG-resistant disease, characterized by a sensitivity of 77% and specificity of 86%.

For clarity:

| Criteria                                  | Condition Met (True) | Score Contribution |
|-------------------------------------------|------------------------|---------------------|
| AST ≥ 200 IU/L                            | Yes                    | 1                   |
| Total Bilirubin ≥ 0.9 mg/dL               | Yes                    | 1                   |
| C-reactive Protein ≥ 7 mg/dL              | Yes                    | 1                   |

The final output consists of the computed score and its interpretation:

- If the score is 2 or more, it indicates a high probability of IVIG resistance, with the given sensitivity and specificity values.
- If the score is less than 2, no specific interpretation is provided by this calculator, indicating that the likelihood of resistance is lower based on the parameters considered.

The Sano score is a clinical calculator used to predict the unresponsiveness to Intravenous Immunoglobulin (IVIG) therapy in patients with Kawasaki disease. Kawasaki disease is a condition that primarily affects children and causes inflammation in the walls of medium-sized arteries throughout the body. The Sano score is particularly useful in identifying patients who are at high risk of being resistant to IVIG therapy, which is the standard treatment for Kawasaki disease. This allows for early intervention with additional or alternative treatments to prevent complications such as coronary artery aneurysms. The Sano score includes variables such as age, days of illness, platelet count, and levels of aspartate aminotransferase (AST), sodium, and C-reactive protein (CRP). It is not applicable to patients without Kawasaki disease or those who have already started IVIG therapy.

Sano score for predicting unresponsiveness to IVIG therapy