The Systematic Coronary Risk Evaluation 2 (SCORE2) is a risk stratification tool specifically designed for the European population. It is utilized to estimate the 10-year risk of fatal cardiovascular disease (CVD) in individuals aged 40-69 years who do not have pre-existing CVD or diabetes. The SCORE2 model incorporates several risk factors including age, sex, smoking status, systolic blood pressure, and total cholesterol levels.
The primary clinical utility of the SCORE2 is to guide primary prevention strategies by identifying individuals at high risk of fatal CVD events. It aids clinicians in making informed decisions about the initiation and intensity of preventive interventions such as lifestyle modifications and pharmacotherapy.
The SCORE2 is not applicable to individuals with pre-existing CVD, those outside the age range of 40-69 years, or those with conditions that significantly alter cardiovascular risk such as diabetes mellitus or chronic kidney disease. Furthermore, it may not accurately predict CVD risk in populations outside Europe due to differences in risk factor prevalence and CVD mortality rates.
Reference
SCORE working group and ESC Cardiovascular risk collaboration. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. Eur Heart J. 2021 Jul 1;42(25):2439-2454.
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