The TNM classification system for adrenocortical carcinoma involves evaluating three aspects: the size and extent of the tumor, lymph node involvement, and presence of metastasis. Based on user input, a cancer stage is assigned according to established criteria.

The calculator takes three user inputs:

1. Tumor Classification (T): Options include Tx (primary tumor cannot be assessed), T0 (no evidence of primary tumor), T1 (tumor is 5 cm or smaller without extra-adrenal invasion), T2 (tumor is larger than 5 cm without extra-adrenal invasion), T3 (tumor of any size with local invasion but not invading adjacent organs), and T4 (tumor of any size invading adjacent organs or large blood vessels).

2. Lymph Node Classification (N): Options include Nx (regional lymph nodes cannot be assessed), N0 (no regional lymph node metastasis), and N1 (regional lymph node metastasis present).

3. Metastasis Classification (M): Options include M0 (no distant metastasis) and M1 (distant metastasis present).

The computation involves evaluating these inputs to determine the cancer stage:

- Stage I is assigned if the tumor is T1, with no lymph node metastasis (N0) and no distant metastasis (M0).
- Stage II is assigned if the tumor is T2, with no lymph node metastasis (N0) and no distant metastasis (M0).
- Stage III is assigned if the following conditions are met: either the tumor is T1 or T2 with regional lymph node metastasis (N1) and no distant metastasis (M0), or the tumor is either T3 or T4 with no lymph node metastasis (N0) and no distant metastasis (M0).
- Stage IV is assigned if the tumor is any T category (T1, T2, T3, T4) with any lymph node status (Nx, N0, N1) and distant metastasis (M1).

If none of the above conditions are met, the result is that the stage cannot be fully assessed.

The calculation systematically assesses tumor size and local invasion, lymph node involvement, and distant metastasis to provide a stage outcome, reflecting the complexity of the disease and its progression. If no input is provided for any category, the result will suggest selecting inputs to obtain an assessment.

The TNM classification for adrenocortical carcinoma is a clinical staging system developed by the American Joint Committee on Cancer (AJCC). It is designed for the stratification of patients with adrenocortical carcinoma, a rare malignancy of the adrenal cortex, based on the extent of the disease. This system aids in determining the prognosis and guiding treatment decisions.

The primary components of this classification system include three parameters: T (Tumor), N (Nodes), and M (Metastasis). The T category describes the size of the primary tumor and whether it has invaded nearby structures. The N category indicates whether the cancer has spread to nearby (regional) lymph nodes. The M category describes whether the cancer has metastasized to other parts of the body. Each of these parameters is further divided into subcategories to provide a more detailed description of the disease extent.

The final stage is determined by combining the T, N, and M categories according to the AJCC guidelines. The stages range from I (early stage) to IV (advanced stage), with each stage further divided into A and B subcategories. The higher the stage, the more advanced the disease and the poorer the prognosis.

Exclusion criteria for the TNM classification for adrenocortical carcinoma include patients with benign adrenal tumors and those with non-adrenal malignancies.