The TNM Classification calculator for uterine leiomyosarcoma and endometrial stromal sarcoma uses three input classifications: tumor classification (T), lymph node classification (N), and metastasis classification (M). It processes these inputs to determine the cancer staging.

For tumor classification, the options are as follows:
- Tx: Primary tumor cannot be assessed
- T0: No evidence of primary tumor
- T1a: Tumor limited to uterus, <= 5 cm
- T1b: Tumor limited to uterus, > 5 cm
- T2a: Tumor invading adnexa
- T2b: Tumor invading other pelvic tissues
- T3a: Tumor invading abdominal tissues, 1 site
- T3b: Tumor invading abdominal tissues, >= 2 sites
- T4: Tumor invading bladder or rectum

For lymph node classification, the options are:
- Nx: Regional lymph nodes cannot be assessed
- N0: No regional lymph node metastasis
- N0(i+): Isolated tumor cells in regional lymph nodes < 0.2 mm
- N1: Regional lymph node metastasis present

For metastasis classification, the options are:
- M0: No distant metastasis
- M1: Distant metastasis present

The combinations of these classifications are mapped to cancer stages as follows:

- Stage IA: Tumor limited to uterus (T1a), no regional lymph node metastasis or isolated tumor cells in regional lymph nodes (N0 or N0(i+)), and no distant metastasis (M0).
- Stage IB: Tumor limited to uterus, > 5 cm (T1b), no regional lymph node metastasis or isolated tumor cells (N0 or N0(i+)), and no distant metastasis (M0).
- Stage II: Tumor invading adnexa or other pelvic tissues (T2a or T2b), no regional lymph node metastasis or isolated tumor cells (N0 or N0(i+)), and no distant metastasis (M0).
- Stage IIIA: Tumor invading abdominal tissues at 1 site (T3a), no regional lymph node metastasis or isolated tumor cells (N0 or N0(i+)), and no distant metastasis (M0).
- Stage IIIB: Tumor invading abdominal tissues at >= 2 sites (T3b), no regional lymph node metastasis or isolated tumor cells (N0 or N0(i+)), and no distant metastasis (M0).
- Stage IIIC: Tumors from T1 to T3 with regional lymph node metastasis present (N1) and no distant metastasis (M0).
- Stage IVA: Tumor invading bladder or rectum (T4) regardless of lymph node involvement, and no distant metastasis (M0).
- Stage IVB: Any primary tumor or lymph node classification with distant metastasis present (M1).

The calculator in question is the TNM Classification for Uterine Leiomyosarcoma and Endometrial Stromal Sarcoma. TNM stands for Tumor, Node, Metastasis, a system used for staging cancer. This specific TNM classification is applicable to patients diagnosed with uterine leiomyosarcoma and endometrial stromal sarcoma, two types of rare uterine cancers.

The clinical utility of this calculator is to stage the cancer, which is crucial for determining the appropriate treatment strategy and for predicting patient prognosis. The TNM system evaluates the size and extent of the tumor (T), whether the cancer has spread to nearby lymph nodes (N), and whether there has been distant metastasis (M).

There are no specific exclusion criteria for the use of this calculator. However, it is not applicable to other types of cancer or to patients who have not been diagnosed with uterine leiomyosarcoma or endometrial stromal sarcoma. It is also important to note that the TNM classification should be used in conjunction with other clinical information and diagnostic tests for a comprehensive evaluation of the patient's condition.

TNM classification for uterine leiomyosarcoma and endometrial stromal sarcoma