Amlodipine

Class
Antihypertensives
Subclass
Dihydropyridine calcium channel blockers
Substance name
amLODIPine besylate, amlodipine besilate
Brand names
Norvasc®
Common formulations
Tablet
Contained in
Amlodipine / atorvastatin (Caduet®)
Amlodipine / benazepril (Lotrel®)
Amlodipine / valsartan (Exforge®)
Amlodipine / valsartan / hydrochlorothiazide (Exforge HCT®)
Olmesartan / amlodipine / hydrochlorothiazide (Tribenzor®)
Telmisartan / amlodipine (Twynsta®)
Dosage and administration
Adults patients
Coronary artery disease
•
5-10 mg PO daily
Hypertension
•
5-10 mg PO daily
Stable angina
•
5-10 mg PO daily
Vasospastic angina
•
5-10 mg PO daily
Diabetic nephropathy • Off-label
•
10 mg PO daily
Drug-induced muscle cramps • Caused by vismodegib • Off-label
•
10 mg PO daily
Use caution in patients with hypotension.
Isolated systolic hypertension • Off-label
•
5 mg PO daily
LVH • Off-label
•
5-10 mg PO daily
Pulmonary arterial hypertension • Off-label
•
Start at: 5 mg PO daily
•
Maintenance: 15-30 mg PO daily
Raynaud's phenomenon • Off-label
•
5-20 mg PO daily
Indications for use
Labeled indications
Adults
•
Treatment of coronary artery disease
•
Treatment of hypertension
•
Treatment of stable angina
•
Treatment of vasospastic angina
Children
•
Treatment of hypertension
Off-label indications
Adults
•
Treatment of Raynaud's phenomenon
•
Treatment of diabetic nephropathy
•
Treatment of drug-induced muscle cramps (caused by vismodegib)
•
Treatment of isolated systolic hypertension
•
Treatment of LVH
•
Treatment of pulmonary arterial hypertension
Safety risks
Contraindications
Hypersensitivity to amlodipine or its components
Warnings and precautions
Exacerbation of angina pectoris, myocardial infarction
•
Use extreme caution in patients with severe obstructive coronary artery disease.
Hypotension
•
Use caution in patients with severe aortic stenosis.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
Renal replacement therapy
Continuous renal replacement
•
Use acceptable. No dose adjustment required.
Intermittent hemodialysis
•
Use acceptable. No dose adjustment required.
Peritoneal dialysis
•
Use acceptable. No dose adjustment required.
Hepatic impairment
Child-Pugh A (mild)
•
Start at dose of 2.5 mg/day for hypertension and at 5 mg/day for angina.
Child-Pugh B (moderate)
•
Start at dose of 2.5 mg/day for hypertension and at 5 mg daily for angina.
Child-Pugh C (severe)
•
Start at dose of 2.5 mg/day for hypertension and at 5 mg daily for angina. Titrate slowly.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: C
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in animals.
Breastfeeding
Use only if benefits outweigh potential risks.
•
Halt breastfeeding temporarily.
Undetectable levels in breastfed infants.
No overt adverse effects reported in breastfed infants.
Adverse reactions
Very common > 10%
•
Peripheral edema
Common 1-10%
•
Abdominal pain, arthralgia, asthenia, dizziness, dyspnea, skin rash, fatigue, headache, myalgia, nausea, palpitations, skin flushing, skin flushing, somnolence, urticaria, sexual dysfunction
Uncommon < 1%
•
Acute pancreatitis, angioedema, conjunctivitis, ↓ WBC count, ↓ platelet count, diaphoresis, gingival swelling, heart failure, erythema multiforme, ↑ blood glucose, peripheral neuropathy, purpura, anxiety, back pain, constipation, dysphagia, depression, diplopia, dry mouth, eye pain, flatulence, hypoesthesia, insomnia, loss of appetite, change in taste, malaise, muscle cramps, nervousness, tachycardia, nightmares, nocturia, nosebleed, pruritus, paresthesia, rigors, syncope, tinnitus, urinary frequency, dysuria, vertigo, vomiting, weight gain, weight loss, Stevens-Johnson syndrome, tremor, vasculitis
Unknown frequency
•
Bradycardia, cardiac arrhythmias, gynecomastia, ↑ liver enzymes, ascites, akathisia, parkinsonism, jaundice, myocardial infarction, toxic epidermal necrolysis, acute interstitial nephritis
Interactions
Drug(s)
Check Interactions
Reset

What did you think about this content?

Create free account

Sign up for free to access the full drug resource