Glyburide / metformin
Class
Hypoglycemic agents
Subclass
Sulfonylurea / biguanide combination
Substance name
Glyburide / metFORMIN, glibenclamide / metformin
Brand names
Glucovance®
Contains
Glyburide
Metformin
Common formulations
Film-coated tablet
See also
Metformin ER (Fortamet®, Glumetza®)
Dosage and administration
Adults patients
Treatment of diabetes mellitus type 2
Indications for use
Labeled indications
Adults
Safety risks
Contraindications
Hypersensitivity to glyburide/metformin or its components
G6PD deficiency
Metabolic acidosis
T1DM or diabetic ketoacidosis
Use of iodine-containing contrast medium
Concomitant use of bosentan
Warnings and precautions
Cardiovascular mortality
Decreased blood glucose
Decreased serum glyburide levels
Decreased serum vitamin B12
Lactic acidosis
Specific populations
Renal impairment
eGFR > 45 mL/min/1.73 m²
eGFR 30-45 mL/min/1.73 m²
eGFR < 30 mL/min/1.73 m²
Renal replacement therapy
Any modality
Hepatic impairment
Any severity
Substantial chronic alcohol consumption
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: C
Breastfeeding
Use only if benefits outweigh potential risks.
Low levels in breastfed infants (5-25%).
May potentially cause adverse effects in breastfed infants.
Adverse reactions
Very common > 10%
Common 1-10%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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