Olopatadine

Intranasal
Ophthalmic
Class
Antihistamines
Subclass
Second-generation H1-antihistamines
Substance name
Olopatadine hydrochloride
Brand names
Patanase®
Common formulations
Nasal spray
Contained in
Olopatadine / mometasone (Ryaltris®)
Dosage and administration
Adults patients
Symptomatic relief of allergic rhinitis • Seasonal
•
2 spray(s) per nostril IN BID (665 mcg/spray)
Indications for use
Labeled indications
Adults
•
Symptomatic relief of allergic rhinitis (seasonal)
Safety risks
Contraindications
Hypersensitivity to olopatadine or its components
Concomitant use of alcohol or other CNS depressants
Warnings and precautions
Nosebleed, nasal ulcers, nasal septum perforation
•
Maintain a high level of suspicion, as olopatadine has been associated with an increased risk of local nasal effects. Perform a nasal examination before initiating olopatadine and periodically during treatment.
Somnolence
•
Use extreme caution in patients performing activities requiring mental alertness, such as driving or operating machinery.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
Renal replacement therapy
Any modality
•
Use acceptable. No dose adjustment required.
Hepatic impairment
Any severity
•
Use acceptable. No dose adjustment required.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B1
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in animals.
Breastfeeding
Use only if benefits outweigh potential risks.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
•
Bitter taste
Common 1-10%
•
Cough, headache, nosebleed, postnasal drip, throat pain, urinary tract infections, upper respiratory tract infections
Uncommon < 1%
•
↑ serum CK, influenza virus infection, dry mouth, throat irritation, fatigue, nasopharyngitis, somnolence
Unknown frequency
•
Nasal septum perforation, nasal ulcers, anosmia, reduced sense of smell
Interactions
Drug(s)
Check Interactions
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