Prednisolone acetate

Class
Steroid hormones
Subclass
Glucocorticoids
Substance name
Prednisolone acetate
Brand names
Pred Forte®, Pred Mild®
Common formulations
Ophthalmic suspension
Dosage and administration
Adults patients
Treatment of ocular inflammatory disease • Palpebra or conjunctiva or cornea or sclera
•
1-2 gtt OPHTH q6-12h
Consider increasing dosing frequency during the initial 24-48 hours if necessary.
Indications for use
Labeled indications
Adults
•
Treatment of ocular inflammatory disease (palpebra or conjunctiva or cornea or sclera)
Safety risks
Contraindications
Hypersensitivity to prednisolone or its components or other corticosteroids
Acute ocular infections
•
Do not use ophthalmic prednisolone in patients with acute untreated purulent ocular infections, in most viral diseases of the cornea and conjunctiva, including herpes simplex keratitis, vaccinia, and varicella, ocular mycobacterial infection, or fungal diseases of ocular structures.
Warnings and precautions
Corneal perforation
•
Use caution in patients with thin corneal or scleral tissue.
Delayed wound healing, bleb formation
•
Use caution in patients after cataract surgery.
Drug hypersensitivity reaction
•
Use caution in patients with possible sulfite hypersensitivity, as prednisolone acetate suspension contains sodium bisulfite.
Exacerbation of glaucoma
•
Use caution in patients with glaucoma. Monitor intraocular pressure.
Exacerbation of herpes simplex ocular infection
•
Use caution in patients with a history of ocular herpes simplex.
Glaucoma, cataract, ocular infections
•
Use caution in patients taking the drug for a prolonged period. Monitor intraocular pressure if prednisolone is used for > 10 days.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
Renal replacement therapy
Any modality
•
Use acceptable. No dose adjustment required.
Hepatic impairment
Any severity
•
Use acceptable. No dose adjustment required.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: A
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in humans.
Breastfeeding
Halt breastfeeding temporarily.
Unknown drug levels in breastfed infants.
No overt adverse effects reported in breastfed infants.
No overt adverse effects on lactation reported.
Adverse reactions
Unknown frequency
•
Allergic reactions, anterior uveitis, cataract, conjunctival injection, delayed wound healing, glaucoma, ↑ intraocular pressure, infections, keratitis, ocular infections, optic nerve disorder, ptosis, blurred vision, burning sensation, dysgeusia, foreign body sensation in the eyes, conjunctivitis, corneal ulcers, mydriasis, corneal perforation, headache, itchy eyes, skin rash, urticaria, eye pain
Interactions
Drug(s)
Check Interactions
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