Rabeprazole DR
Class
Acid suppression agents
Subclass
Proton pump inhibitors
Substance name
RABEprazole sodium DR
Brand names
Aciphex®
Common formulations
Tablet
Dosage and administration
Adults patients
Symptomatic relief
GERD
Treatment
Duodenal ulcer
GERD • Erosive or ulcerative
H. pylori infection • Triple therapy
Pathological hypersecretory gastrointestinal conditions
Barrett's esophagus • Off-label
Eosinophilic esophagitis • Off-label
Functional dyspepsia • Off-label
H. pylori infection • Off-label
Other off-label uses
Indications for use
Labeled indications
Adults
Off-label indications
Adults
Safety risks
Contraindications
Hypersensitivity to rabeprazole or its components or to other substituted benzimidazoles
Concomitant use of rilpivirine
Warnings and precautions
Acute interstitial nephritis
Bone fracture
C. difficile infection
Cutaneous lupus erythematosus, SLE
Decreased serum calcium
Decreased serum magnesium
Fundic gland polyps
Gastric cancer
Increased serum methotrexate levels
Mask symptoms of gastric cancer
Prolonged PT, increased INR
Severe cutaneous adverse reactions
Vitamin B12 deficiency
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
Renal replacement therapy
Any modality
Hepatic impairment
Child-Pugh A (mild)
Child-Pugh B (moderate)
Child-Pugh C (severe)
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B1
Breastfeeding
Use only if benefits outweigh potential risks.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Some adverse effects on lactation reported.
Adverse reactions
Common 1-10%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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