Hypothermia in DNDD
Trial question
What is the role of therapeutic hypothermia in low-risk nonpumped brain-dead kidney donors?
Study design
Multi-center
Single blinded
RCT
Population
Characteristics of study participants
37.0% female
63.0% male
N = 481
481 patients (176 female, 305 male).
Inclusion criteria: brain-dead kidney donors deemed to be low risk and not requiring machine perfusion.
Key exclusion criteria: donation after cardiac death donor; coagulopathy; hemodynamic instability; electrolyte deficiencies; pre-existing kidney disease.
Interventions
N=236 hypothermia (maintenance of therapeutic hypothermia, 34-35 °Celsius).
N=245 normothermia (maintenance of normothermia, 36.5-37.5 °Celsius).
Primary outcome
Delayed graft function in kidney transplant recipients
17%
18%
18.0 %
13.5 %
9.0 %
4.5 %
0.0 %
Hypothermia
Normothermia
No significant
difference ↔
No significant difference in delayed graft function in kidney transplant recipients (17% vs. 18%; OR 0.92, 95% CI 0.64 to 1.33).
Conclusion
In brain-dead kidney donors deemed to be low risk and not requiring machine perfusion, hypothermia was not superior to normothermia with respect to delayed graft function in kidney transplant recipients.
Reference
Madhukar S Patel, Juan D Salcedo-Betancourt, Christina Saunders et al. Therapeutic Hypothermia in Low-Risk Nonpumped Brain-Dead Kidney Donors: A Randomized Clinical Trial. JAMA Netw Open. 2024 Feb 5;7(2):e2353785.
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