NordICC
Trial question
What is the effect of colonoscopy screening on the risks of CRC?
Study design
Multi-center
Open label
RCT
Population
Characteristics of study participants
50.0% female
50.0% male
N = 84585
84585 patients (42186 female, 42399 male).
Inclusion criteria: healthy men and women 55 to 64 years of age who had previously not undergone screening.
Key exclusion criteria: death or diagnosis of CRC before trial entry.
Interventions
N=28220 colonoscopy screening (one-time colonoscopy screening).
N=56365 usual care (no screening or intervention within the trial).
Primary outcome
Colorectal cancer at 10 years
0.98%
1.2%
1.2 %
0.9 %
0.6 %
0.3 %
0.0 %
Colonoscopy
screening
Usual
care
Significant
decrease ▼
NNT = 454
Significant decrease in CRC at 10 years (0.98% vs. 1.2%; RR 0.82, 95% CI 0.7 to 0.93).
Secondary outcomes
No significant difference in death from CRC at 10 years (0.28% vs. 0.31%; RR 0.9, 95% CI 0.64 to 1.16).
No significant difference in death from any cause at 10 years (11.03% vs. 11.04%; RR 0.99, 99% CI 0.96 to 1.04).
Conclusion
In healthy men and women 55 to 64 years of age who had previously not undergone screening, colonoscopy screening was superior to usual care with respect to CRC at 10 years.
Reference
Michael Bretthauer, Magnus Løberg, Paulina Wieszczy et al. Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death. N Engl J Med. 2022 Oct 27;387(17):1547-1556.
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