TREATY
Trial question
Is a regimen of time-restricted with calorie restriction superior to calorie restriction only in patients with obesity?
Study design
Single center
Open label
RCT
Population
Characteristics of study participants
49.0% female
51.0% male
N = 139
139 patients (68 female, 71 male).
Inclusion criteria: adult patients with obesity.
Key exclusion criteria: acute or chronic viral hepatitis; malignant tumors; serious cardiovascular or cerebrovascular disease; type 1 and T2DM; serious liver dysfunction; CKD.
Interventions
N=69 time-restricted eating (eating only between 8:00 am and 4:00 pm with calorie restriction).
N=70 daily calorie restriction (continuous energy restriction without a restriction of feeding time).
Primary outcome
Reduction in body weight at 1 year
8 kg
6.3 kg
8.0 kg
6.0 kg
4.0 kg
2.0 kg
0.0 kg
Time-restricted
eating
Daily calorie
restriction
No significant
difference ↔
No significant difference in reduction in body weight at 1 year (8 kg vs. 6.3 kg; AD 1.8 kg, 95% CI -0.4 to 4).
Secondary outcomes
No significant difference in reduction in BMI at 1 year (2.9 vs. 2.3; AD 0.7 , 95% CI -0.1 to 1.5).
No significant difference in reduction in waist circumference at 1 year (8.8 cm vs. 7 cm; AD 1.8 cm, 95% CI -0.5 to 4).
No significant difference in reduction in body fat mass at 1 year (5.9 kg vs. 4.5 kg; AD 1.5 kg, 95% CI -0.2 to 3.1).
Safety outcomes
No significant difference in adverse events.
Conclusion
In adult patients with obesity, time-restricted eating was not superior to daily calorie restriction with respect to reduction in body weight at 1 year.
Reference
Deying Liu, Yan Huang, Chensihan Huang et al. Calorie Restriction with or without Time-Restricted Eating in Weight Loss. N Engl J Med. 2022 Apr 21;386(16):1495-1504.
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